1. Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases,Hangzhou,China,310009
2. Department of Pediatrics, No. 903 Hospital of PLA Joint Logistic Support Force,Hangzhou,China,310013
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Recent progress of nanomedicine in managing dry eye disease[J]. 眼科实践与研究新进展, 2024,4(1):23-31.
Zeen Lv, Su Li, Guixiang Zeng, et al. Recent progress of nanomedicine in managing dry eye disease[J]. AOPR, 2024,4(1):23-31.
Recent progress of nanomedicine in managing dry eye disease[J]. 眼科实践与研究新进展, 2024,4(1):23-31. DOI: 10.1016/j.aopr.2024.01.008.
Zeen Lv, Su Li, Guixiang Zeng, et al. Recent progress of nanomedicine in managing dry eye disease[J]. AOPR, 2024,4(1):23-31. DOI: 10.1016/j.aopr.2024.01.008.
BackgroundDry eye disease (DED) is a commonly reported ocular complaint that has garnered significant attention in recent research. The global occurrence of DED ranges from 5% to 50%
impacting a substantial proportion of individuals worldwide with increasing frequency. Although topical administration remains the mainstream drug delivery method for ocular diseases
it suffers from drawbacks such as low bioavailability
rapid drug metabolism
and frequent administration requirements. Fortunately
the advancements in nanomedicine offer effective solutions to address the aforementioned issues and provide significant assistance in the treatment of DED.Main textDED is considered a multifactorial disease of the ocular surface and tear film
in which the integrity of tear film function and structure plays a crucial role in maintaining the homeostasis of the ocular surface. The conventional treatment for DED involves the utilization of artificial tear products
cyclosporin
corticosteroids
mucin secretagogues
and nonsteroidal anti-inflammatory drugs. Furthermore
nanomedicine is presently a significant field of study
with numerous clinical trials underway for various nanotherapeutics including nanoemulsions
nanosuspensions
liposomes
and micelles. Notably
some of these innovative nanoformulations have already received FDA approval as novel remedies for DED
and the advancement of nanomedicine is poised to offer enhanced prospects to solve the shortcomings of existing treatments for DED partially.ConclusionsThis article provides an overview of the latest advancements in nanomedicine for DED treatment
while the field of DED treatment is expected to witness a remarkable breakthrough shortly with the development of nanomedicine
bringing promising prospects for patients worldwide suffering conditions.
Dry eye diseaseNanoparticlesDrug deliveryNanomedicineOcular surface
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