1 C. Patterson, L. Guariguata, G. Dahlquist, et al.Diabetes in the young - a global view and worldwide estimates of numbers of children with type 1 diabetes Diabetes Res Clin Pract, 103 (2014), pp. 161-175, 10.1016/j.diabres.2013.11.005

2 R.R. Bourne, G.A. Stevens, R.A. White, et al.Causes of vision loss worldwide, 1990-2010: a systematic analysis Lancet Global Health, 1 (2013), pp. e339-e349, 10.1016/s2214-109x(13)70113-x

3 J.M. Forbes, M.E. CooperMechanisms of diabetic complications Physiol Rev, 93 (2013), pp. 137-188, 10.1152/physrev.00045.2011

4 P.H. Scanlon, S.J. Aldington, I.M. StrattonEpidemiological issues in diabetic retinopathy Middle East Afr J Ophthalmol, 20 (2013), pp. 293-300, 10.4103/0974-9233.120007

5 R. Simó, A.W. Stitt, T.W. GardnerNeurodegeneration in diabetic retinopathy: does it really matter? Diabetologia, 61 (2018), pp. 1902-1912, 10.1007/s00125-018-4692-1

6 H.B. Lim, Y.I. Shin, M.W. Lee, et al.Longitudinal changes in the peripapillary retinal nerve fiber layer thickness of patients with type 2 diabetes JAMA Ophthalmol, 137 (2019), pp. 1125-1132, 10.1001/jamaophthalmol.2019.2537

7 R. Simó, C. HernándezNeurodegeneration in the diabetic eye: new insights and therapeutic perspectives Trends Endocrinol Metabol, 25 (2014), pp. 23-33, 10.1016/j.tem.2013.09.005

8 X. Chen, C. Nie, Y. Gong, et al.Peripapillary retinal nerve fiber layer changes in preclinical diabetic retinopathy: a meta-analysis PLoS One, 10 (2015), Article e0125919, 10.1371/journal.pone.0125919

9 D. Cao, D. Yang, H. Yu, et al.Optic nerve head perfusion changes preceding peripapillary retinal nerve fibre layer thinning in preclinical diabetic retinopathy Clin Exp Ophthalmol, 47 (2019), pp. 219-225, 10.1111/ceo.13390

10 B. Zhang, Y. Chou, X. Zhao, et al.Early detection of microvascular impairments with optical coherence tomography angiography in diabetic patients without clinical retinopathy: a meta-analysis Am J Ophthalmol, 222 (2021), pp. 226-237, 10.1016/j.ajo.2020.09.032

11 S.T. Demir, A. Ucar, G.K. Elitok, et al.Evaluation of retinal neurovascular structures by optical coherence tomography and optical coherence tomography angiography in children and adolescents with type 1 diabetes mellitus without clinical sign of diabetic retinopathy Graefes Arch Clin Exp Ophthalmol, 258 (2020), pp. 2363-2372, 10.1007/s00417-020-04842-1

12 T. Li, Y. Jia, S. Wang, et al.Retinal microvascular abnormalities in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy Invest Ophthalmol Vis Sci, 60 (2019), pp. 990-998, 10.1167/iovs.18-25499

13 I. Laíns, J.C. Wang, Y. Cui, et al.Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) Prog Retin Eye Res, 84 (2021), Article 100951, 10.1016/j.preteyeres.2021.100951

14 Q. Zhao, W.L. Yang, X.N. Wang, et al.Repeatability and reproducibility of quantitative assessment of the retinal microvasculature using optical coherence tomography angiography based on optical microangiography Biomed Environ Sci, 31 (2018), pp. 407-412, 10.3967/bes2018.054

15 G. Agiostratidou, H. Anhalt, D. Ball, et al.Standardizing clinically meaningful outcome measures beyond HbA(1c) for type 1 diabetes: a consensus report of the American association of clinical endocrinologists, the American association of diabetes educators, the American diabetes association, the endocrine society, JDRF international, the leona M. and harry B. Helmsley charitable trust, the pediatric endocrine society, and the T1D exchange Diabetes Care, 40 (2017), pp. 1622-1630, 10.2337/dc17-1624

16 A. Petersmann, D. Müller-Wieland, U.A. Müller, et al.Definition, classification and diagnosis of diabetes mellitus Exp Clin Endocrinol Diabetes, 127 (2019), pp. S1-s7, 10.1055/a-1018-9078

17 S. Roy, T.S. Kern, B. Song, et al.Mechanistic insights into pathological changes in the diabetic retina: implications for targeting diabetic retinopathy Am J Pathol, 187 (2017), pp. 9-19, 10.1016/j.ajpath.2016.08.022

18 M. Inanc, K. Tekin, H. Kiziltoprak, et al.Changes in retinal microcirculation precede the clinical onset of diabetic retinopathy in children with type 1 diabetes mellitus Am J Ophthalmol, 207 (2019), pp. 37-44, 10.1016/j.ajo.2019.04.011

19 R. Sacconi, M. Casaluci, E. Borrelli, et al.Multimodal imaging assessment of vascular and neurodegenerative retinal alterations in type 1 diabetic patients without fundoscopic signs of diabetic retinopathy J Clin Med, 8 (2019), 10.3390/jcm8091409

20 D.C. Sousa, I. Leal, S. Moreira, et al.Optical coherence tomography angiography study of the retinal vascular plexuses in type 1 diabetes without retinopathy Eye, 34 (2020), pp. 307-311, 10.1038/s41433-019-0513-0

21 E. Pilotto, T. Torresin, F. Leonardi, et al.Retinal microvascular and neuronal changes are also present, even if differently, in adolescents with type 1 diabetes without clinical diabetic retinopathy J Clin Med, 11 (2022), 10.3390/jcm11143982

22 Q. Yu, Y. Xiao, Q. Lin, et al.Two-year longitudinal study on changes in thickness of the retinal nerve fiber layer and ganglion cell layer in children with type 1 diabetes mellitus without visual impairment or diabetic retinopathy Curr Eye Res, 47 (2022), pp. 1218-1225, 10.1080/02713683.2022.2079142

23 J. Ye, M. Wang, M. Shen, et al.Deep retinal capillary plexus decreasing correlated with the outer retinal layer alteration and visual acuity impairment in pathological myopia Invest Ophthalmol Vis Sci, 61 (2020), p. 45, 10.1167/iovs.61.4.45

24 A.C. Onishi, P.L. Nesper, P.K. Roberts, et al.Importance of considering the middle capillary plexus on OCT angiography in diabetic retinopathy Invest Ophthalmol Vis Sci, 59 (2018), pp. 2167-2176, 10.1167/iovs.17-23304

25 Standring S. Gray's Anatomy (41tst ed.). Edinburgh: Elsevier Churchill Livingstone. doi..

26 C. Balaratnasingam, D. An, Y. Sakurada, et al.Comparisons between histology and optical coherence tomography angiography of the periarterial capillary-free zone Am J Ophthalmol, 189 (2018), pp. 55-64, 10.1016/j.ajo.2018.02.007

27 T. BekTransretinal histopathological changes in capillary-free areas of diabetic retinopathy Acta Ophthalmol, 72 (1994), pp. 409-415, 10.1111/j.1755-3768.1994.tb02787.x

28 J. Moore, S. Bagley, G. Ireland, et al.Three dimensional analysis of microaneurysms in the human diabetic retina J Anat, 194 (Pt 1) (1999), pp. 89-100, 10.1046/j.1469-7580.1999.19410089.x

29 Y.X. Wang, S. Panda-Jonas, J.B. JonasOptic nerve head anatomy in myopia and glaucoma, including parapapillary zones alpha, beta, gamma and delta: histology and clinical features Prog Retin Eye Res, 83 (2021), Article 100933, 10.1016/j.preteyeres.2020.100933

30 H. Shpitzer, L. Lazar, S. Shalitin, et al.Good glycemic control at puberty in boys with type 1 diabetes is important for final height J Diabetes, 13 (2021), pp. 998-1006, 10.1111/1753-0407.13214

31 E.B. Parente, V. Harjutsalo, C. Forsblom, et al.Waist-height ratio and the risk of severe diabetic eye disease in type 1 diabetes: a 15-year cohort study J Clin Endocrinol Metab, 107 (2022), pp. e653-e662, 10.1210/clinem/dgab671

32 L. Chen, D.J. Magliano, P.Z. ZimmetThe worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives Nat Rev Endocrinol, 8 (2011), pp. 228-236, 10.1038/nrendo.2011.183

33 M. Wurm, L. Kuhnemund, L. Maier, et al.Hemoglobin A1c and retinal arteriolar narrowing in children with type 1 diabetes: the diagnostics of early atherosclerosis risk in kids study Pediatr Diabetes, 20 (2019), pp. 622-628, 10.1111/pedi.12858