Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study

Hao Wang; Qiang Ye; Weihe Xu; Jing Wang; Jianhan Liu; Xintong Xu; Wenfang Zhang

doi:10.1016/j.aopr.2023.07.003

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Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study

Full Length Article | 更新时间：2023-11-15

- Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study
- Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study
- 眼科实践与研究新进展 2023年3卷第4期页码：159-170
- 作者机构：
  
  1. Department of Ophthalmology, Lanzhou University Second Hospital,Lanzhou,China,730000
  2. Medical School of Chinese PLA,Beijing,China,100853
  3. Department of Ophthalmology, Chinese PLA General Hospital,Beijing,China,100853
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2023.07.003
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Hao Wang, Qiang Ye, Weihe Xu, 等. Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study[J]. 眼科实践与研究新进展, 2023,3(4):159-170.

Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study[J]. AOPR, 2023,3(4):159-170.
Hao Wang, Qiang Ye, Weihe Xu, 等. Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study[J]. 眼科实践与研究新进展, 2023,3(4):159-170. DOI： 10.1016/j.aopr.2023.07.003.

Research trends of worldwide ophthalmologic randomized controlled trials in the 21st century: A bibliometric study[J]. AOPR, 2023,3(4):159-170. DOI： 10.1016/j.aopr.2023.07.003.

摘要

Background,Randomized controlled trials (RCTs) are often considered the gold standard and the cornerstone for clinical practice. However, bibliometric studies on worldwide RCTs of ophthalmology published in the 21st century have not been reported in detail yet. This study aims to perform a bibliometric study and visualization analysis of worldwide ophthalmologic RCTs in the 21st century.,Methods,Global ophthalmologic RCTs from 2000 to 2022 were searched in the Web of Science Core Collection. The number of publications, country/region, institution, author, journal, and research hotspots of RCTs were analyzed using HistCite, VOSviewer, CiteSpace, and Excel software.,Results,2366 institutions and 90 journals from 83 countries/regions participated in the publication of 1769 global ophthalmologic RCTs, with the United States leading in the number of volumes and research field, and the Moorfields Eye Hospital contributing to the most publications. Ophthalmology received the greatest number of publications and co-citations. Jeffrey S. Heier owned the most publications and Jost B. Jonas owned the most co-citations. The knowledge foundations of global ophthalmologic RCTs were mainly retinopathy, glaucoma, dry eye disease (DED), and cataracts, and anti-vascular endothelial growth factor (VEGF) therapy (ranibizumab), topical ocular hypotensive medication, laser trabeculoplasty. Anti-VEGF therapy for age-related macular degeneration (AMD), DME (diabetic macular edema), and DED, the use of new diagnostic tools, and myopia were the hottest research highlights. Anti-VEGF therapy, prompt laser, triamcinolone, and verteporfin photodynamic therapy for AMD, DME, and CNV (choroidal neovascularization), DED, myopia, and open-angle glaucoma were the research hotspots with the longest duration. The future research hotspots might be DED and the prevention and control of myopia.,Conclusions,Overall, the number of global ophthalmologic RCTs in the 21st century was keeping growing, there was an imbalance between the regions and institutions, and more efforts are required to raise the quantity, quality, and global impact of high-quality clinical evidence in developing countries/regions.

Abstract

关键词

OphthalmologyRandomized controlled trials (RCTs)The 21st centuryWorldwideBibliometricResearch trends

Keywords

OphthalmologyRandomized controlled trials (RCTs)The 21st centuryWorldwideBibliometricResearch trends

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