A UV-related risk analysis in ophthalmic malignancies: Increased UV exposure may cause ocular malignancies

Xiaojun Ju; Alexander C. Rokohl; Xueting Li; Yongwei Guo; Ke Yao; Wanlin Fan; Ludwig M. Heindl

doi:10.1016/j.aopr.2024.04.001

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A UV-related risk analysis in ophthalmic malignancies: Increased UV exposure may cause ocular malignancies

Full Length Article | 更新时间：2024-05-29

- A UV-related risk analysis in ophthalmic malignancies: Increased UV exposure may cause ocular malignancies
- AOPR Vol. 4, Issue 2, Pages: 98-105(2024)
- 作者机构：
  
  1. Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne,Cologne,Germany
  2. Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf,Cologne,Germany
  3. Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine
  4. Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases,Zhejiang,Hangzhou,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.04.001
  CLC：
- Published：2024，
扫描看全文
Xiaojun Ju, Alexander C. Rokohl, Xueting Li, et al. A UV-related risk analysis in ophthalmic malignancies: Increased UV exposure may cause ocular malignancies. [J]. AOPR 4(2):98-105(2024)
DOI：

Xiaojun Ju, Alexander C. Rokohl, Xueting Li, et al. A UV-related risk analysis in ophthalmic malignancies: Increased UV exposure may cause ocular malignancies. [J]. AOPR 4(2):98-105(2024) DOI： 10.1016/j.aopr.2024.04.001.

摘要

Abstract

PurposeTo explore the role of ultraviolet radiation (UVR) in the occurrence and development of various ocular malignancies.MethodsIn this article

we retrieved ocular malignancy data from the Global Cancer Observatory (GCO) and performed correlation analysis with the global UV index and sunshine duration. We searched for associated studies using the following databases: Embase

Pubmed

Cochrane Library

and Google Scholar. We conducted the literature by searching the Mesh terms denoting an exposure of interest ("UV radiation"

"ultraviolet rays"

and "ocular malignancies"

All studies included are published until December 30

2023 without language restrictions.ResultsThe mechanisms and epidemiological statistics of UVR on the onset and progression of eyelid malignancies are the most studied and clear. The role of UVR in conjunctival melanoma is similar to that in eyelid melanoma. The relationship between uveal melanoma and UVR is controversial

however

it may have at least a certain impact on its prognosis. UVR causes ocular surface squamous neoplasia by further activating HPV infection.ConclusionsUVR is a decisive risk factor for ocular malignancies

but the incidence of ultraviolet-induced tumors is also affected by many other factors. A correct and comprehensive understanding of the mechanisms of UVR in the pathogenesis of ocular malignant tumors can provide patients with more effective and selective immune regulation strategies.

关键词

Keywords

Ultraviolet radiationEyelid malignanciesConjunctival melanomaUveal melanomaOcular surface squamous neoplasia

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