Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges

Yifei Niu; Junfeng Ji; Ke Yao; Qiuli Fu

doi:10.1016/j.aopr.2024.02.001

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Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges

Review | 更新时间：2024-05-29

- Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges
- AOPR Vol. 4, Issue 2, Pages: 52-64(2024)
- 作者机构：
  
  1. Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine,Zhejiang Province,Hangzhou,China
  2. Zhejiang Provincial Key Lab of Ophthalmology,Zhejiang Province,Hangzhou,China
  3. Center of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University,Zhejiang Province,Hangzhou,China
  4. Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine,Hangzhou,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.02.001
  CLC：
- Published：2024，
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Yifei Niu, Junfeng Ji, Ke Yao, et al. Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges. [J]. AOPR 4(2):52-64(2024)
DOI：

Yifei Niu, Junfeng Ji, Ke Yao, et al. Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges. [J]. AOPR 4(2):52-64(2024) DOI： 10.1016/j.aopr.2024.02.001.

摘要

Abstract

BackgroundDegenerate eye disorders

such as glaucoma

cataracts and age-related macular degeneration (AMD)

are prevalent causes of blindness and visual impairment worldwide. Other eye disorders

including limbal stem cell deficiency (LSCD)

dry eye diseases (DED)

and retinitis pigmentosa (RP)

result in symptoms such as ocular discomfort and impaired visual function

significantly impacting quality of life. Traditional therapies are limited

primarily focus on delaying disease progression

while emerging stem cell therapy directly targets ocular tissues

aiming to restore ocular function by reconstructing ocular tissue.Main textThe utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant

owing to the regenerative and malleable properties of stem cells and their functional cells. Currently

stem cell therapy for ophthalmopathy involves various cell types

such as embryonic stem cells (ESCs)

induced pluripotent stem cells (iPSCs)

mesenchymal stem cells (MSCs)

and retinal progenitor cells (RPCs). In the current article

we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the retina. These therapies aim to address the loss of functional cells

restore damaged ocular tissue and or in a paracrine-mediated manner. We also provide an overview of the ocular disorders that stem cell therapy is targeting

as well as the difficulties and opportunities in this field.ConclusionsStem cells can not only promote tissue regeneration but also release exosomes to mitigate inflammation and provide neuroprotection

making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.

关键词

Keywords

Stem cellOcular diseasesInduced pluripotent stem cellsMesenchymal stem cellsCataractsGlaucomaDiabetic retinopathyRetinal degenerative diseases

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