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1. ,Wenzhou,China
2. Eye Center of the Second Affiliated Hospital, Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Zhejiang University School of Medicine,Hangzhou,China
纸质出版日期:2024,
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Lingman Zheng, Zhiyong Liao, Jian Zou. Animal modeling for myopia[J]. 眼科实践与研究新进展, 2024,4(4):173-181.
LINGMAN ZHENG, ZHIYONG LIAO, JIAN ZOU. Animal modeling for myopia. [J]. Aopr, 2024, 4(4): 173-181.
Lingman Zheng, Zhiyong Liao, Jian Zou. Animal modeling for myopia[J]. 眼科实践与研究新进展, 2024,4(4):173-181. DOI: 10.1016/j.aopr.2024.06.001.
LINGMAN ZHENG, ZHIYONG LIAO, JIAN ZOU. Animal modeling for myopia. [J]. Aopr, 2024, 4(4): 173-181. DOI: 10.1016/j.aopr.2024.06.001.
BackgroundMyopia is one of the most common eye diseases globally
and has become an increasingly serious health concern among adolescents. Understanding the factors contributing to the onset of myopia and the strategies to slow its progression is critical to reducing its prevalence.Main textAnimal models are key to understanding of the etiology of human diseases. Various experimental animal models have been developed to mimic human myopia
including chickens
rhesus monkeys
marmosets
mice
tree shrews
guinea pigs and zebrafish. Studies using these animal models have provided evidences and perspectives on the regulation of eye growth and refractive development. This review summarizes the characteristics of these models
the induction methods
common indicators of myopia in animal models
and recent findings on the pathogenic mechanism of myopia.ConclusionsInvestigations using experimental animal models have provided valuable information and insights into the pathogenic mechanisms of human myopia and its treatment strategies.
MyopiaExperimental myopia animal modelsForm-deprivated myopiaLens-induced myopiaEye growthRefractive developmentCorneal remodeling
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