Mechanisms of electrical stimulation in eye diseases: A narrative review

Jinfeng Liu; Andre K.H. Ma; Kwok Fai So; Vincent W.H. Lee; Kin Chiu

doi:10.1016/j.aopr.2022.100060

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Mechanisms of electrical stimulation in eye diseases: A narrative review

更新时间：2023-11-15

- Mechanisms of electrical stimulation in eye diseases: A narrative review
- Mechanisms of electrical stimulation in eye diseases: A narrative review
- 眼科实践与研究新进展 2022年2卷第2期页码：100060
- 作者机构：
  
  1. ,Hong Kong,SAR,China
  2. ,UK
  3. ,Hong Kong,SAR,China
  4. ,Hong Kong,SAR,China
  5. ,Guangdong,Guangzhou,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2022.100060
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Mechanisms of electrical stimulation in eye diseases: A narrative review[J]. 眼科实践与研究新进展, 2022,2(2):100060.

Jinfeng Liu, Andre K.H. Ma, Kwok Fai So, et al. Mechanisms of electrical stimulation in eye diseases: A narrative review[J]. AOPR, 2022,2(2):100060.
Mechanisms of electrical stimulation in eye diseases: A narrative review[J]. 眼科实践与研究新进展, 2022,2(2):100060. DOI： 10.1016/j.aopr.2022.100060.

Jinfeng Liu, Andre K.H. Ma, Kwok Fai So, et al. Mechanisms of electrical stimulation in eye diseases: A narrative review[J]. AOPR, 2022,2(2):100060. DOI： 10.1016/j.aopr.2022.100060.

摘要

Background,In the last two decades, electrical stimulation (ES) has been tested in patients with various eye diseases and shows great treatment potential in retinitis pigmentosa and optic neuropathy. However, the clinical application of ES in ophthalmology is currently limited. On the one hand, optimization and standardization of ES protocols is still an unmet need. On the other hand, poor understanding of the underlying mechanisms has hindered clinical exploitation.,Main Text,Numerous experimental studies have been conducted to identify the treatment potential of ES in eye diseases and to explore the related cellular and molecular mechanisms. In this review, we summarized the in vitro and in vivo evidence related to cellular and tissue response to ES in eye diseases. We highlighted several pathways that may be utilized by ES to impose its effects on the diseased retina.,Conclusions,Therapeutic effect of ES in retinal degenerative diseases might through preventing neuronal apoptosis, promoting neuronal regeneration, increasing neurotrophic factors production in Müller cells, inhibiting microglial activation, enhancing retinal blood flow, and modulating brain plasticity. Future studies are suggested to analyse changes in specific retinal cells for optimizing the treatment parameters and choosing the best fit ES delivery method in target diseases.

Abstract

关键词

Keywords

Electrical stimulationEye diseasesOphthalmologyRetinitis pigmentosaOptic neuropathy

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