Research progress on the impact of cataract surgery on corneal endothelial cells

Chen Yang; Qi An; Han Zhou; Hongyan Ge

doi:10.1016/j.aopr.2024.08.002

您当前的位置：

首页 >

文章列表页 >

Research progress on the impact of cataract surgery on corneal endothelial cells

Review | 更新时间：2024-12-14

- Research progress on the impact of cataract surgery on corneal endothelial cells
- AOPR Vol. 4, Issue 4, Pages: 194-201(2024)
- 作者机构：
  
  1. ,Harbin,China
  2. Department of Cardiology, The First Affiliated Hospital of Harbin Medical University,Harbin,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.08.002
  CLC：
- Published：2024，
- 稿件说明：
移动端阅览
CHEN YANG, QI AN, HAN ZHOU, et al. Research progress on the impact of cataract surgery on corneal endothelial cells. [J]. Aopr, 2024, 4(4): 194-201.
DOI：

CHEN YANG, QI AN, HAN ZHOU, et al. Research progress on the impact of cataract surgery on corneal endothelial cells. [J]. Aopr, 2024, 4(4): 194-201. DOI： 10.1016/j.aopr.2024.08.002.

摘要

Abstract

BackgroundCataracts are a common eye disease and a major cause of blindness in China and worldwide. In China

the incidence of cataracts among people over 60 years old is as high as 80%. Surgery is the primary treatment for various types of cataracts

but such invasive procedures can affect corneal endothelial cells to some extent.Main textCataract surgery can damage corneal endothelial cells

leading to complications such as corneal edema in mild cases. Severe damage can result in endothelial decompensation

necessitating secondary corneal endothelial transplantation. Preoperative thorough assessment of endothelial status

intraoperative endothelial protection measures

and postoperative active use of medications to prevent further damage to endothelial cells can reduce endothelial cell loss. Factors influencing endothelial cell status include whether the patient has related systemic diseases or ocular conditions

the hardness of the nucleus

the choice of surgical incision

the method of nuclear fragmentation

the type of viscoelastic agent used

the orientation of the phacoemulsification needle bevel

the duration and energy of ultrasound use

the choice of fluid control system

the use of protective auxiliary instruments

the application of intraocular lens scaffold technology

femtosecond laser assistance

and the use of certain medications.ConclusionsActively regulating the factors affecting corneal endothelial cells to reduce damage related to cataract surgery is crucial. This paper reviews the existing literature on various factors affecting corneal endothelial cells during cataract surgery and explores future developments and research directions.

关键词

Keywords

CataractCorneal endothelial cellsSurgical treatment

references

1 R. Fang, Y.F. Yu, E.J. Li, et al.Global, regional, national burden and gender disparity of cataract: findings from the global burden of disease study 2019 BMC Publ Health, 22 (1) (2022), p. 2068, 10.1186/s12889-022-14491-0

2 L.N. Boyers, C. Karimkhani, J. Hilton, W. Richheimer, R.P. DellavalleGlobal burden of eye and vision disease as reflected in the Cochrane Database of Systematic Reviews JAMA Ophthalmol, 133 (1) (2015), pp. 25-31, 10.1001/jamaophthalmol.2014.3527

3 Y. Liu, H. Sun, P. Guo, et al.Characterization and prospective of human corneal endothelial progenitors Int J Med Sci, 14 (8) (2017), pp. 705-710, 10.7150/ijms.19018

4 A.S. Goldstein, B.J. Janson, J.M. Skeie, J.J. Ling, M.A. GreinerThe effects of diabetes mellitus on the corneal endothelium: a review Surv Ophthalmol, 65 (4) (2020), pp. 438-450, 10.1016/j.survophthal.2019.12.009

5 S. Bamdad, A. Bolkheir, M.R. Sedaghat, M. MotamedChanges in corneal thickness and corneal endothelial cell density after phacoemulsification cataract surgery: a double-blind randomized trial Electron Physician, 10 (4) (2018), pp. 6616-6623, 10.19082/6616

6 A. Grzybowski, P. Kanclerz, V. Huerva, F.J. Ascaso, R. TuuminenDiabetes and phacoemulsification cataract surgery: difficulties, risks and potential complications J Clin Med, 8 (5) (2019), 10.3390/jcm8050716

7 A. El-Agamy, S. AlsubaieCorneal endothelium and central corneal thickness changes in type 2 diabetes mellitus Clin Ophthalmol, 11 (2017), pp. 481-486, 10.2147/OPTH.S126217 From NLM PubMed-not-MEDLINE

8 B. Chowdhury, S. Bhadra, P. Mittal, K. ShyamCorneal endothelial morphology and central corneal thickness in type 2 diabetes mellitus patients Indian J Ophthalmol, 69 (7) (2021), pp. 1718-1724, 10.4103/ijo.IJO_3120_20

9 J.S. Lee, J.E. Lee, H.Y. Choi, B.S. Oum, B.M. ChoCorneal endothelial cell change after phacoemulsification relative to the severity of diabetic retinopathy J Cataract Refract Surg, 31 (4) (2005), pp. 742-749, 10.1016/j.jcrs.2004.09.035

10 M. Hugod, A. Storr-Paulsen, J.C. Norregaard, J. Nicolini, A.B. Larsen, J. ThulesenCorneal endothelial cell changes associated with cataract surgery in patients with type 2 diabetes mellitus Cornea, 30 (7) (2011), pp. 749-753, 10.1097/ICO.0b013e31820142d9

11 P. Papadakou, I. Chatziralli, M. Papathanassiou, et al.The effect of diabetes mellitus on corneal endothelial cells and central corneal thickness: a case-control study Ophthalmic Res, 63 (6) (2020), pp. 550-554, 10.1159/000507197

12 A.L. Ciorba, G. Roiu, A.M. Abdelhamid, S. Saber, S. CavaluEvaluation of the corneal endothelium following cataract surgery in diabetic and non-diabetic patients Diagnostics, 13 (6) (2023), 10.3390/diagnostics13061115

13 R. Singh, A.K. Sharma, V. Katiyar, G. Kumar, S.K. GuptaCorneal endothelial changes following cataract surgery in hard nuclear cataract: randomized trial comparing phacoemulsification to manual small-incision cataract surgery Indian J Ophthalmol, 70 (11) (2022), pp. 3904-3909, 10.4103/ijo.IJO_1304_22

14 M. Singh, D. Mishra, B.P. Sinha, A. Anand, S. SinghalCorneal endothelial protection during manual small-incision cataract surgery: a narrative review Indian J Ophthalmol, 70 (11) (2022), pp. 3791-3796, 10.4103/ijo.IJO_1048_22

15 K. Inoue, Y. Tokuda, Y. Inoue, S. Amano, T. Oshika, J. InoueCorneal endothelial cell morphology in patients undergoing cataract surgery Cornea, 21 (4) (2002), pp. 360-363, 10.1097/00003226-200205000-00006

16 M.J. Chen, C.J. Liu, C.Y. Cheng, S.M. LeeCorneal status in primary angle-closure glaucoma with a history of acute attack J Glaucoma, 21 (1) (2012), pp. 12-16, 10.1097/IJG.0b013e3181fc800a

17 T. Ianchulev, S. Lane, M. Masis, et al.Corneal endothelial cell density and morphology after phacoemulsification in patients with primary open-angle glaucoma and cataracts: 2-year results of a randomized multicenter trial Cornea, 38 (3) (2019), pp. 325-331, 10.1097/ICO.0000000000001826

18 V. Patel, M. MuhtasebEndothelial cell loss after pIOL implantation for high myopia J Cataract Refract Surg, 34 (9) (2008), pp. 1424-1425, 10.1016/j.jcrs.2008.05.037

19 J. Coullet, L. Mahieu, F. Malecaze, et al.Severe endothelial cell loss following uneventful angle-supported phakic intraocular lens implantation for high myopia J Cataract Refract Surg, 33 (8) (2007), pp. 1477-1481, 10.1016/j.jcrs.2007.03.061

20 H.B. Hwang, B. Lyu, H.B. Yim, N.Y. LeeEndothelial cell loss after phacoemulsification according to different anterior chamber depths J Ophthalmol, 2015 (2015), Article 210716, 10.1155/2015/210716 From NLM PubMed-not-MEDLINE

21 M. Khalid, S.S. Ameen, N. Ayub, M.A. MehboobEffects of anterior chamber depth and axial length on corneal endothelial cell density after phacoemulsification Pakistan J Med Sci, 35 (1) (2019), pp. 200-204, 10.12669/pjms.35.1.92

22 A. Reuschel, H. Bogatsch, N. Oertel, R. WiedemannInfluence of anterior chamber depth, anterior chamber volume, axial length, and lens density on postoperative endothelial cell loss Graefes Arch Clin Exp Ophthalmol, 253 (5) (2015), pp. 745-752, 10.1007/s00417-015-2934-1

23 Y. Jiang, W.Y. Shi, F.J. Li, T. Wang[Efficacy of double-incision extracapsular cataract extraction in the treatment of hard-nucleus cataract with low corneal endothelial cell density] Zhonghua Yan Ke Za Zhi, 56 (2) (2020), pp. 126-130, 10.3760/cma.j.issn.0412-4081.2020.02.008

24 X.W. Yang, Y. Gao, Y.Q. Jiang, Y.J. Zhou[Effect of femtosecond laser-assisted phacoemulsification on corneal endothelium and prognosis of diabetic patients with cataract with different nuclear hardness] Zhonghua Yan Ke Za Zhi, 60 (6) (2024), pp. 511-517, 10.3760/cma.j.cn112142-20231223-00305

25 W.M. BourneBiology of the corneal endothelium in health and disease Eye, 17 (8) (2003), pp. 912-918, 10.1038/sj.eye.6700559

26 L.E.W. Frifelt, Y. Subhi, L.M. Holm, A. SinghImpact of tobacco use on corneal thickness and endothelial health: a systematic review with meta-analyses Acta Ophthalmol, 100 (1) (2022), pp. 26-34, 10.1111/aos.14897

27 D.C. Sousa, I. Leal, M.Y. Faria, L.A. PintoA rare manifestation of uveitis-glaucoma-hyphema syndrome J Curr Glaucoma Pract, 10 (2) (2016), pp. 76-78, 10.5005/jp-journals-10008-1205

28 R. Vaiciuliene, N. Rylskyte, G. Baguzyte, V. JasinskasRisk factors for fluctuations in corneal endothelial cell density Review Exp Ther Med, 23 (2) (2022), p. 129, 10.3892/etm.2021.11052

29 A.E. Ostern, G.F. Sandvik, L. DrolsumLate in-the-bag intraocular lens dislocation in eyes with pseudoexfoliation syndrome Acta Ophthalmol, 92 (2) (2014), pp. 184-191, 10.1111/aos.12024

30 N. Rosado-Adames, N.A. AfshariThe changing fate of the corneal endothelium in cataract surgery Curr Opin Ophthalmol, 23 (1) (2012), pp. 3-6, 10.1097/ICU.0b013e32834e4b5f

31 C. Jin, X. Chen, A. Law, et al.Different-sized incisions for phacoemulsification in age-related cataract Cochrane Database Syst Rev, 9 (9) (2017), Article CD010510, 10.1002/14651858.CD010510.pub2

32 J.K. Rono, U. NirghinVisual outcome after small incision cataract surgery of patients in a Kenyan Hospital Contributors Afr Health Sci, 23 (2) (2023), pp. 469-477, 10.4314/ahs.v23i2.54

33 M. Hepokur, E.B. Kizilay, E. Durmus, V. Aykut, F. Esen, H. OguzThe influence of corneal incision size on endothelial cell loss and surgically induced astigmatism following phacoemulsification cataract surgery North Clin Istanb, 9 (4) (2022), pp. 385-390, 10.14744/nci.2021.81084

34 E. Song, X. Li, M.C. Bi, et al.A comparison of surgical efficacy between a 1.8-mm microincision and 3.2-mm and 5.5-mm incisions for phacoemulsification Int J Ophthalmol, 11 (3) (2018), pp. 516-519, 10.18240/ijo.2018.03.25

35 Y. Dai, Z. Liu, W. Wang, et al.Incidence of incision-related Descemet membrane detachment using phacoemulsification with trapezoid vs conventional 2.2-mm clear corneal incision: a randomized clinical trial JAMA Ophthalmol, 139 (11) (2021), pp. 1228-1234, 10.1001/jamaophthalmol.2021.4148

36 N. Cheong, S.W. Chui, S.H.L. Poon, H.L. Wong, K.C. Shih, Y.K. ChanEmerging treatments for corneal endothelium decompensation - a systematic review Graefes Arch Clin Exp Ophthalmol, 262 (2) (2024), pp. 381-393, 10.1007/s00417-023-06129-7

37 M. Honjo, H. Tanihara, A. Negi, et al.Trabeculotomy ab externo, cataract extraction, and intraocular lens implantation: preliminary report J Cataract Refract Surg, 22 (5) (1996), pp. 601-606, 10.1016/s0886-3350(96)80017-4

38 Y. Han, N. QiNumerical study of critical straight, frown, and chevron incisions in small incision cataract surgery Front Bioeng Biotechnol, 11 (2023), Article 1283293, 10.3389/fbioe.2023.1283293 From NLM PubMed-not-MEDLINE

39 A.M. Al Mahmood, S.A. Al-Swailem, A. BehrensClear corneal incision in cataract surgery Middle East Afr J Ophthalmol, 21 (1) (2014), pp. 25-31, 10.4103/0974-9233.124084

40 Q.Y. Yi, J. Huang, N. Chen, et al.Managing dislocated hard lens nuclei: 23-gauge vitrectomy and lens extraction via a corneoscleral limbal incision versus 23-gauge vitrectomy and phacofragmentation J Cataract Refract Surg, 45 (4) (2019), pp. 451-456, 10.1016/j.jcrs.2018.10.042

41 O.O. Abdullah, H. OksuzA simplified sclerocorneal tunnel approach in performing pediatric cataract surgery Oman J Ophthalmol, 17 (1) (2024), pp. 91-95, 10.4103/ojo.ojo_321_22

42 W. Song, X. Chen, W. WangEffect of steep meridian clear corneal incisions in phacoemulsification Eur J Ophthalmol, 25 (5) (2015), pp. 422-425, 10.5301/ejo.5000575

43 S. Pershing, A. KumarPhacoemulsification versus extracapsular cataract extraction: where do we stand? Curr Opin Ophthalmol, 22 (1) (2011), pp. 37-42, 10.1097/ICU.0b013e3283414fb3

44 S.S. Modi, J.A. Davison, T. WaltersSafety, efficacy, and intraoperative characteristics of DisCoVisc and Healon ophthalmic viscosurgical devices for cataract surgery Clin Ophthalmol, 5 (2011), pp. 1381-1389, 10.2147/OPTH.S22243 From NLM PubMed-not-MEDLINE

45 C.K. Joo, Y.H. KimPhacoemulsification with a bevel-down phaco tip: phaco-drill J Cataract Refract Surg, 23 (8) (1997), pp. 1149-1152, 10.1016/s0886-3350(97)80307-0

46 T. Mizuguchi, M. Horiguchi, A. TanikawaVisualization of the posterior surface of the lens nucleus with triamcinolone acetonide in phacoemulsification Eur J Ophthalmol, 31 (6) (2021), pp. 2977-2980, 10.1177/1120672120977356

47 M. Benitez Martinez, D. Baeza Moyano, Gonzalez-Lezcano, R.A. PhacoemulsificationProposals for improvement in its application Healthcare (Basel), 9 (11) (2021), 10.3390/healthcare9111603

48 J.Y. Choi, C.S. Cho, Y.K. HanApplication of thermoreversible hydrogel (poloxamer 407) to protect the corneal endothelium during phacoemulsification in porcine and rabbit eyes J Cataract Refract Surg, 44 (10) (2018), pp. 1254-1260, 10.1016/j.jcrs.2018.04.043

49 W.J. Yang, X.H. Wang, F. Zhao, Z.M. Mei, S. Li, Y. XiangTorsional and burst mode phacoemulsification for patients with hard nuclear cataract: a randomized control study Medicine (Baltim), 98 (22) (2019), Article e15870, 10.1097/MD.0000000000015870

50 S. Gigliola, G. Sborgia, A. Niro, et al.One-handed rotational phacoemulsification technique Clin Ophthalmol, 15 (2021), pp. 431-435, 10.2147/OPTH.S281857 From NLM PubMed-not-MEDLINE

51 C.M. Nicoli, R. Dimalanta, K.M. MillerExperimental anterior chamber maintenance in active versus passive phacoemulsification fluidics systems J Cataract Refract Surg, 42 (1) (2016), pp. 157-162, 10.1016/j.jcrs.2015.08.017

52 Y. Liu, J. Hong, X. ChenComparisons of the clinical outcomes of Centurion((R)) active fluidics system with a low IOP setting and gravity fluidics system with a normal IOP setting for cataract patients with low corneal endothelial cell density Front Med, 10 (2023), Article 1294808, 10.3389/fmed.2023.1294808 From NLM PubMed-not-MEDLINE

53 H.W. Roberts, A.C. Day, D.P. O'BrartFemtosecond laser-assisted cataract surgery: a review Eur J Ophthalmol, 30 (3) (2020), pp. 417-429, 10.1177/1120672119893291

54 D. Dzhaber, O. Mustafa, F. Alsaleh, A. Mihailovic, Y.J. DaoudComparison of changes in corneal endothelial cell density and central corneal thickness between conventional and femtosecond laser-assisted cataract surgery: a randomised, controlled clinical trial Br J Ophthalmol, 104 (2) (2020), pp. 225-229, 10.1136/bjophthalmol-2018-313723

55 A. Narayan, J.R. Evans, D. O'Brart, C. Bunce, D.M. Gore, A.C. DayLaser-assisted cataract surgery versus standard ultrasound phacoemulsification cataract surgery Cochrane Database Syst Rev, 6 (6) (2023), p. CD010735, 10.1002/14651858.CD010735.pub3

56 R.G. Abell, N.M. Kerr, B.J. VoteToward zero effective phacoemulsification time using femtosecond laser pretreatment Ophthalmology, 120 (5) (2013), pp. 942-948, 10.1016/j.ophtha.2012.11.045

57 N. Chikamoto, N. Takahashi, M. Wakuta, Y. Fujitsu, T. NishidaRecovery of corneal thickness promoted by glucocorticoid administration after phacoemulsification in eyes affected by Fuchs' dystrophy Jpn J Ophthalmol, 52 (4) (2008), pp. 336-339, 10.1007/s10384-008-0534-x

58 F. Sali, V. Aykut, A. Kunbaz, et al.Endothelial loss following postoperative intracameral triamcinolone acetonide and subconjunctival dexamethasone injections Cutan Ocul Toxicol, 42 (4) (2023), pp. 237-242, 10.1080/15569527.2023.2239897

59 Y. Wen, X. Zhang, M. Chen, D. HanSodium hyaluronate in the treatment of dry eye after cataract surgery: a meta-analysis Ann Palliat Med, 9 (3) (2020), pp. 927-939, 10.21037/apm-20-695

60 H. Fujimoto, Y. Setoguchi, J. KiryuThe ROCK inhibitor ripasudil shows an endothelial protective effect in patients with low corneal endothelial cell density after cataract surgery Transl Vis Sci Technol, 10 (4) (2021), p. 18, 10.1167/tvst.10.4.18

61 T.J. Fan, S.X. Wu, G.J. JiangApoptotic effects of norfloxacin on corneal endothelial cells Naunyn-Schmiedeberg’s Arch Pharmacol, 393 (1) (2020), pp. 77-88, 10.1007/s00210-019-01711-5

62 J.H. Park, M. Kim, R.S. Chuck, C.Y. ParkEvaluation of moxifloxacin-induced cytotoxicity on human corneal endothelial cells Sci Rep, 11 (1) (2021), p. 6250, 10.1038/s41598-021-85834-x

63 H.S. Hwang, Y.S. Ahn, Y.K. ChoPreoperative mannitolization can decrease corneal endothelial cell damage after cataract surgery Curr Eye Res, 41 (9) (2016), pp. 1161-1165, 10.3109/02713683.2015.1101138

64 S. MishimaClinical investigations on the corneal endothelium Ophthalmology, 89 (6) (1982), pp. 525-530, 10.1016/s0161-6420(82)34755-7

65 G.A. PeymanIntraocular irrigating solutions Ophthalmology, 102 (10) (1995), pp. 1413-1414, 10.1016/s0161-6420(95)38040-2

66 A. Rubowitz, E.I. Assia, M. Rosner, M. TopazAntioxidant protection against corneal damage by free radicals during phacoemulsification Invest Ophthalmol Vis Sci, 44 (5) (2003), pp. 1866-1870, 10.1167/iovs.02-0892

67 W. Uthaisang-Tanechpongtamb, W. Limtrakarn, S. ReepolmahaThe effect of temperature of eye irrigation solution to reduce corneal endothelial cell loss during phacoemulsification: an in vitro model study J Med Assoc Thai, 95 (Suppl 12) (2012), pp. S83-S89 From NLM Medline

68 B.K. Nayak, E.K. JainComparison of corneal endothelial cell loss during phacoemulsification using continuous anterior chamber infusion versus those using ophthalmic viscosurgical device: randomized controlled trial Indian J Ophthalmol, 57 (2) (2009), pp. 99-103, 10.4103/0301-4738.45500

69 H. Shimada, S. Arai, H. Nakashizuka, T. Hattori, M. YuzawaReduced anterior chamber contamination by frequent surface irrigation with diluted iodine solutions during cataract surgery Acta Ophthalmol, 95 (5) (2017), pp. e373-e378, 10.1111/aos.13390

70 M.V. Cicinelli, J.C. Buchan, M. Nicholson, V. Varadaraj, R.C. KhannaCataracts Lancet, 401 (10374) (2023), pp. 377-389, 10.1016/S0140-6736(22)01839-6

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Complications of high myopia: An update from clinical manifestations to underlying mechanisms

Cataract: Advances in surgery and whether surgery remains the only treatment in future

Stereopsis after bilateral implantation of Toric intraocular lenses in high myopic cataract patients with astigmatism

Role of Rapamycin and 3-MA in oxidative damage of HLECs caused by two doses of UVB radiation

Related Author

Xiangjia Zhu

Yi Lu

Jiao Qi

Wenwen He

Jiaqi Meng

Yu Du

Jingjie Xu

Ke Yao

Related Institution

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University

NHC Key Laboratory of Myopia and Related Eye Diseases, Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences

Shanghai Key Laboratory of Visual Impairment and Restoration

State Key Laboratory of Medical Neurobiology, Fudan University

Eye Center, Second Affiliated Hospital of School of Medicine, Zhejiang University

⁰