Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction

Zhenwei Qin; Yirui Zhu; Jiale Lu; Lin Lin; Yanan Huo; Haoyu Wang; Chen Qiao; Xiangxi Chen; Jianhua Wu; Qingyan Zeng; Xiuming Jin

doi:10.1016/j.aopr.2024.06.002

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Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction

Full Length Article | 更新时间：2024-12-14

- Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction
- AOPR Vol. 4, Issue 4, Pages: 182-188(2024)
- 作者机构：
  
  1. Eye Center of the 2nd Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang Provincial Key Lab of Ophthalmology,Hangzhou,China
  2. Wuhan Aier Eye Hospital,Wuhan,China
  3. Hankou Aier Eye Hospital,Wuhan,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.06.002
  CLC：
- Published：2024，
- 稿件说明：
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ZHENWEI QIN, YIRUI ZHU, JIALE LU, et al. Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction. [J]. Aopr, 2024, 4(4): 182-188.
DOI：

ZHENWEI QIN, YIRUI ZHU, JIALE LU, et al. Therapeutic effectiveness of different machines in intense pulsed light treatment of meibomian gland dysfunction. [J]. Aopr, 2024, 4(4): 182-188. DOI： 10.1016/j.aopr.2024.06.002.

摘要

Abstract

PurposeThis study aimed to determine the therapeutic effectiveness of different machines in intense pulsed light (IPL) treatment of meibomian gland dysfunction (MGD).Methods213 subjects diagnosed with MGD underwent three sessions of IPL treatment in a control (M22) treatment group or experimental (OPL-I) treatment group and were followed up three to four weeks after each session. Tear breakup time (TBUT)

meibomian gland secretion scores (MGSS)

meibomian gland meibum scores (MGMS)

corneal fluorescein staining (CFS) scores

and the Standard Patient Evaluation of Eye Dryness (SPEED) was used to assess eye dryness signs and symptoms at baseline and follow-up visits.ResultsTwo machines had the same working principles except that experimental (OPL-I) group consist of a dual filter system. Both groups showed significant improvements (

0.0001) in TBUT

MGSS

MGMS

CFS scores and SPEED scores. Non-inferiority analysis showed no statistically significant differences in any result between the two groups. Various defects appeared on the filter with the extension of usage time. Spectrophotometry showed that light intensity de

creased to 93.5% ± 0.46% past the first filter.ConclusionsIPL treatment completed with different machines have the same effect on improving the symptoms and signs of MGD. The dual filter system in the IPL machine reduces light intensity by approximately 6.5% without affecting its therapeutic effect. It is a feasible measure to ensure double safety and has the significance of popularization not only for MGD but also in other IPL treatment scenarios.

关键词

Keywords

MGDIPLNon-inferiority analysisDual filter system

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