Animal modeling for myopia

Lingman Zheng; Zhiyong Liao; Jian Zou

doi:10.1016/j.aopr.2024.06.001

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Animal modeling for myopia

Review | 更新时间：2024-12-14

- Animal modeling for myopia
- AOPR Vol. 4, Issue 4, Pages: 173-181(2024)
- 作者机构：
  
  1. ,Wenzhou,China
  2. Eye Center of the Second Affiliated Hospital, Center for Genetic Medicine, Zhejiang University International Institute of Medicine, Zhejiang University School of Medicine,Hangzhou,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.06.001
  CLC：
- Published：2024，
- 稿件说明：
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LINGMAN ZHENG, ZHIYONG LIAO, JIAN ZOU. Animal modeling for myopia. [J]. Aopr, 2024, 4(4): 173-181.
DOI：

LINGMAN ZHENG, ZHIYONG LIAO, JIAN ZOU. Animal modeling for myopia. [J]. Aopr, 2024, 4(4): 173-181. DOI： 10.1016/j.aopr.2024.06.001.

摘要

Abstract

BackgroundMyopia is one of the most common eye diseases globally

and has become an increasingly serious health concern among adolescents. Understanding the factors contributing to the onset of myopia and the strategies to slow its progression is critical to reducing its prevalence.Main textAnimal models are key to understanding of the etiology of human diseases. Various experimental animal models have been developed to mimic human myopia

including chickens

rhesus monkeys

marmosets

mice

tree shrews

guinea pigs and zebrafish. Studies using these animal models have provided evidences and perspectives on the regulation of eye growth and refractive development. This review summarizes the characteristics of these models

the induction methods

common indicators of myopia in animal models

and recent findings on the pathogenic mechanism of myopia.ConclusionsInvestigations using experimental animal models have provided valuable information and insights into the pathogenic mechanisms of human myopia and its treatment strategies.

关键词

Keywords

MyopiaExperimental myopia animal modelsForm-deprivated myopiaLens-induced myopiaEye growthRefractive developmentCorneal remodeling

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