Association between glaucoma and stroke: A bidirectional mendelian randomization study

Kai Wang; Xueqi Lin; Siting Sheng; Dan Chen; Xin Liu; Ke Yao

doi:10.1016/j.aopr.2024.04.003

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Association between glaucoma and stroke: A bidirectional mendelian randomization study

Full Length Article | 更新时间：2024-12-14

- Association between glaucoma and stroke: A bidirectional mendelian randomization study
- AOPR Vol. 4, Issue 3, Pages: 147-155(2024)
- 作者机构：
  
  1. Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou,China
  2. Department of Ophthalmology, Zhongshan Hospital, Fudan University,Shanghai,China
  3. Shanghai Institute of Infectious Disease and Biosecurity, Zhongshan Hospital, Fudan University,Shanghai,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2024.04.003
  CLC：
- Published：2024，
- 稿件说明：
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KAI WANG, XUEQI LIN, SITING SHENG, et al. Association between glaucoma and stroke: A bidirectional mendelian randomization study. [J]. Aopr, 2024, 4(3): 147-155.
DOI：

KAI WANG, XUEQI LIN, SITING SHENG, et al. Association between glaucoma and stroke: A bidirectional mendelian randomization study. [J]. Aopr, 2024, 4(3): 147-155. DOI： 10.1016/j.aopr.2024.04.003.

摘要

Abstract

PurposeObservational studies have reported positive associations between glaucoma and stroke; however

controversial results exist. Importantly

the nature of the relationship remains unknown since previous studies were not designed to test causality. Therefore

we aimed to investigate the possible causal relationships between glaucoma and stroke.MethodsOur two-sample Mendelian randomization (MR) encompassed multi-ethnic large-scale genome-wide association studies with more than 20000 cases and 260000 controls for glaucoma

and more than 80000 cases and 630000 controls for stroke. Individual effect estimates for each SNP were combined using the inverse-variance weighted (IVW) method. To avoid potential pleiotropic effects

we adjusted the main results by excluding genetic variants associated with metabolic factors. The weighted median and MR-Egger methods were also used for the sensitivity analysis.ResultsOur MR analysis revealed that glaucoma and its subtypes

including primary open-angle glaucoma and primary angle-closure glaucoma

exhibited no causal role in relation to any stroke (AS)

any ischemic stroke (AIS)

large-artery atherosclerotic stroke (LAS)

small-vessel stroke (SVS)

or cardioembolic stroke (CES) across MR analyses (all

0.05). The null associations remained robust even after adjusting for metabolic-related traits and were consistent in both the European and Asian populations. Furthermore

reverse MR analyses also did not indicate any significant causal effects of AS

AIS

LAS

or CES on glaucoma risk.ConclusionsEvidence from our series of causal inference approaches using large-scale population-based MR analyses did not support causal effects between glaucoma and stroke. These findings suggest that the relationship of glaucoma management and stroke risk prevention should be carefully evaluated in future studies. In turn

stroke diagnosis should not be simply applied to glaucoma risk prediction.

关键词

Keywords

GlaucomaStrokeMendelian randomizationCausationMetabolic-related trait

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