Quantification of vascular morphology in optical coherence tomography angiography in primary open angle glaucoma
- AOPR Vol. 3, Issue 3, Pages: 119-125(2023)
- 作者机构：
1. ,TX,Dallas,USA
2. ,TX,Dallas,USA
- 作者简介：
- 基金信息：
DOI：10.1016/j.aopr.2023.05.002
CLC：
扫 描 看 全 文
Praneeth Kalva, Rubeel Akram, Priya Mekala, et al. Quantification of vascular morphology in optical coherence tomography angiography in primary open angle glaucoma. [J]. AOPR 3(3):119-125(2023)
Praneeth Kalva, Rubeel Akram, Priya Mekala, et al. Quantification of vascular morphology in optical coherence tomography angiography in primary open angle glaucoma. [J]. AOPR 3(3):119-125(2023) DOI： 10.1016/j.aopr.2023.05.002.
摘要
Purpose,To quantitatively measure and compare the vascular morphology in healthy eyes and eyes with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA) scans.,Methods,This is a retrospective and cross-sectional study which include healthy individuals and individuals with POAG that underwent OCTA imaging at an academic center's glaucoma clinic. We analyzed OCTA scans of the macula and optic nerve head (ONH) of one eye from each subject to quantitatively measure vessel density (VD), vessel length density (VLD), and branchpoint density (BPD). We compared these 3 parameters between the healthy and POAG groups and used logistic regression classification models to determine their diagnostic value in differentiating healthy and glaucomatous eyes.,Results,We included 49 healthy subjects and 49 subjects with POAG. After age-adjusted analysis, the parameters of VD, VLD, and BPD were significantly reduced in eyes with POAG (,P, ,<, 0.001) in all scan layers and most significantly around the ONH. The parameter with the best performances were radial peripapillary capillary (RPC) VD [AUC (areas under the curve): 0.939 (0.891, 0.987)] which had statistically higher performances (,P, ,<, 0.05) than parameters in the superficial or deep layers. All 3 parameters in the RPC layer had statistically similar performances.,Conclusions,We found that VD, VLD, and BPD were reduced in glaucomatous eyes. The morphologic parameters of VLD and BPD had similar performances to the traditional parameter of VD in RPC layers. Our results suggest that vascular morphology parameters may provide additional value in the diagnosis and evaluation of glaucoma.
Abstract
Purpose,To quantitatively measure and compare the vascular morphology in healthy eyes and eyes with primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA) scans.,Methods,This is a retrospective and cross-sectional study which include healthy individuals and individuals with POAG that underwent OCTA imaging at an academic center's glaucoma clinic. We analyzed OCTA scans of the macula and optic nerve head (ONH) of one eye from each subject to quantitatively measure vessel density (VD), vessel length density (VLD), and branchpoint density (BPD). We compared these 3 parameters between the healthy and POAG groups and used logistic regression classification models to determine their diagnostic value in differentiating healthy and glaucomatous eyes.,Results,We included 49 healthy subjects and 49 subjects with POAG. After age-adjusted analysis, the parameters of VD, VLD, and BPD were significantly reduced in eyes with POAG (,P, ,<, 0.001) in all scan layers and most significantly around the ONH. The parameter with the best performances were radial peripapillary capillary (RPC) VD [AUC (areas under the curve): 0.939 (0.891, 0.987)] which had statistically higher performances (,P, ,<, 0.05) than parameters in the superficial or deep layers. All 3 parameters in the RPC layer had statistically similar performances.,Conclusions,We found that VD, VLD, and BPD were reduced in glaucomatous eyes. The morphologic parameters of VLD and BPD had similar performances to the traditional parameter of VD in RPC layers. Our results suggest that vascular morphology parameters may provide additional value in the diagnosis and evaluation of glaucoma.
关键词
Keywords
Optical coherence tomography angiographyGlaucomaVessel density
references
1 RN Weinreb, T Aung, FA MedeirosThe pathophysiology and treatment of glaucoma: a review JAMA, 311 (18) (May 14 2014), pp. 1901-1911, 10.1001/jama.2014.3192
2 KKW Chan, F Tang, CCY Tham, et al.Retinal vasculature in glaucoma: a review BMJ Open Ophthalmol, 1 (1) (2017), Article e000032, 10.1136/bmjophth-2016-000032
3 H.L. Rao, Z.S. Pradhan, M.H. Suh, et al.Optical coherence tomography angiography in glaucoma. J glaucoma Apr, 29 (4) (2020), pp. 312-321, 10.1097/ijg.0000000000001463
4 A. Invernizzi, M. Cozzi, G. StaurenghiOptical coherence tomography and optical coherence tomography angiography in uveitis: a review Clin Exp Ophthalmol. Apr, 47 (3) (2019), pp. 357-371, 10.1111/ceo.13470
5 Z. Sun, D. Yang, Z. Tang, et al.Optical coherence tomography angiography in diabetic retinopathy: an updated review Eye (Lond) Jan, 35 (1) (2021), pp. 149-161, 10.1038/s41433-020-01233-y
6 A.C. Werner, L.Q. ShenA review of OCT angiography in glaucoma Semin Ophthalmol, 34 (4) (2019), pp. 279-286, 10.1080/08820538.2019.1620807
7 L. Liu, Y. Jia, H.L. Takusagawa, et al.Optical coherence tomography angiography of the peripapillary retina in glaucoma JAMA Ophthalmol, 133 (9) (2015), pp. 1045-1052, 10.1001/jamaophthalmol.2015.2225
8 A. Yarmohammadi, L.M. Zangwill, A. Diniz-Filho, et al.Optical coherence tomography angiography vessel density in healthy, glaucoma suspect, and glaucoma eyes Investig Ophthalmol Vis Sci, 57 (9) (2016), pp. OCT451-OCT459, 10.1167/iovs.15-18944
9 N.W. El-Nimri, P.I.C. Manalastas, L.M. Zangwill, et al.Superficial and deep macula vessel density in healthy, glaucoma suspect, and glaucoma eyes J Glaucoma, 30 (6) (Jun 1 2021), pp. e276-e284, 10.1097/ijg.0000000000001860
10 Y. Huo, R. Thomas, Y. Guo, et al.Superficial macular vessel density in eyes with mild, moderate, and severe primary open-angle glaucoma Graefe’s Arch Clin Exp Ophthalmol, 259 (7) (2021/07/01 2021), pp. 1955-1963, 10.1007/s00417-021-05120-4
11 R.S. Kumar, N. Anegondi, R.S. Chandapura, et al.Discriminant function of optical coherence tomography angiography to determine disease severity in glaucoma Invest Ophthalmol Vis Sci Nov 1, 57 (14) (2016), pp. 6079-6088, 10.1167/iovs.16-19984
12 H.-Y.L. Park, K.E. Hong, D.Y. Shin, et al.Microvasculature recovery detected using optical coherence tomography angiography and the rate of visual field progression after glaucoma surgery Investig Ophthalmol Vis Sci, 62 (15) (2021), p. 17, 10.1167/iovs.62.15.17 17
13 C. Liu, R.M. Umapathi, E. Atalay, et al.The effect of medical lowering of intraocular pressure on peripapillary and macular blood flow as measured by optical coherence tomography angiography in treatment-naive eyes J Glaucoma, 30 (6) (Jun 1 2021), pp. 465-472, 10.1097/ijg.0000000000001828
14 L. Liu, H.L. Takusagawa, M.F. Greenwald, et al.Optical coherence tomographic angiography study of perfusion recovery after surgical lowering of intraocular pressure Sci Rep, 11 (1) (2021/08/26 2021), Article 17251, 10.1038/s41598-021-96225-7
15 M.K. Durbin, L. An, N.D. Shemonski, et al.Quantification of retinal microvascular density in optical coherence tomographic angiography images in diabetic retinopathy JAMA Ophthalmol, 135 (4) (2017), pp. 370-376, 10.1001/jamaophthalmol.2017.0080
16 M. Alam, D. Le, J.I. Lim, et al.Vascular complexity analysis in optical coherence tomography angiography of diabetic retinopathy Retina Mar 1, 41 (3) (2021), pp. 538-545, 10.1097/iae.0000000000002874
17 Z. Chu, J. Lin, C. Gao, et al.Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography J Biomed Opt, 21 (6) (2016), p. 66008, 10.1117/1.JBO.21.6.066008 66008
18 T.P.H. Lin, Y.M. Wang, K. Ho, et al.Global assessment of arteriolar, venular and capillary changes in normal tension glaucoma Sci Rep, 10 (1) (2020), p. 19222, 10.1038/s41598-020-75784-1 19222
19 K.K.W. Cheng, B.L. Tan, L. Brown, et al.Macular vessel density, branching complexity and foveal avascular zone size in normal tension glaucoma Sci Rep, 11 (1) (2021), p. 1056, 10.1038/s41598-020-80080-z 1056
20 G.M. Richter, B. Sylvester, Z. Chu, et al.Peripapillary microvasculature in the retinal nerve fiber layer in glaucoma by optical coherence tomography angiography: focal structural and functional correlations and diagnostic performance Clin Ophthalmol, 12 (2018), pp. 2285-2296, 10.2147/opth.S179816
21 E. Hodapp, R.K. Parrish, D.R. AndersonClinical Decisions in Glaucoma Mosby Incorporated (1993)
22 E.R. DeLong, D.M. DeLong, D.L. Clarke-PearsonComparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach Biometrics, 44 (3) (1988), pp. 837-845, 10.2307/2531595
23 P. Lu, H. Xiao, C. Liang, et al.Quantitative analysis of microvasculature in macular and peripapillary regions in early primary open-angle glaucoma Curr Eye Res May, 45 (5) (2020), pp. 629-635, 10.1080/02713683.2019.1676912
24 K.L. Hong, B. Burkemper, A.L. Urrea, et al.Hemiretinal asymmetry in peripapillary vessel density in healthy, glaucoma suspect, and glaucoma eyes Am J Ophthalmol, 230 (2021/10/01/2021), pp. 156-165, 10.1016/j.ajo.2021.05.019
25 M. Arya, C.B. Rebhun, A.Y. Alibhai, et al.Parafoveal retinal vessel density assessment by optical coherence tomography angiography in healthy eyes Ophthalmic Surg Lasers Imaging Retina, 49 (10) (Oct 15 2018), pp. S5-s17, 10.3928/23258160-20180814-02
26 J. Chua, C.W.L. Chin, J. Hong, et al.Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography J Hypertens Mar, 37 (3) (2019), pp. 572-580, 10.1097/hjh.0000000000001916
27 B.A. Corliss, C. Mathews, R. Doty, et al.Methods to label, image, and analyze the complex structural architectures of microvascular networks Microcirculation, 26 (5) (2019), Article e12520-e12520, 10.1111/micc.12520
28 C. Bowd, L.M. Zangwill, C.C. Berry, et al.Detecting early glaucoma by assessment of retinal nerve fiber layer thickness and visual function Investig Ophthalmol Vis Sci, 42 (9) (2001), pp. 1993-2003
29 T.-Y. Hou, T.-M. Kuang, Y.-C. Ko, et al.Optic disc and macular vessel density measured by optical coherence tomography angiography in open-angle and angle-closure glaucoma Sci Rep, 10 (1) (2020/03/27 2020), p. 5608, 10.1038/s41598-020-62633-4
30 R.C. Penteado, C. Bowd, J.A. Proudfoot, et al.Diagnostic ability of optical coherence tomography angiography macula vessel density for the diagnosis of glaucoma using difference scan sizes J Glaucoma, 29 (4) (2020), pp. 245-251, 10.1097/ijg.0000000000001447
0
Views
0
下载量
0
CSCD
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.