Research progress of iron metabolism in retinal diseases

Cunzi Li; Chunyu Xiao; Hui Tao; Xianling Tang

doi:10.1016/j.aopr.2023.02.001

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Research progress of iron metabolism in retinal diseases

Review | 更新时间：2023-11-15

- Research progress of iron metabolism in retinal diseases
- AOPR Vol. 3, Issue 2, Pages: 93-100(2023)
- 作者机构：
  
  1. ,Harbin,China
  2. ,Shenzhen,China
  3. ,Harbin,China
- 作者简介：
- 基金信息：
- DOI：10.1016/j.aopr.2023.02.001
  CLC：
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Cunzi Li, Chunyu Xiao, Hui Tao, et al. Research progress of iron metabolism in retinal diseases. [J]. AOPR 3(2):93-100(2023)
DOI：

Cunzi Li, Chunyu Xiao, Hui Tao, et al. Research progress of iron metabolism in retinal diseases. [J]. AOPR 3(2):93-100(2023) DOI： 10.1016/j.aopr.2023.02.001.

摘要

Background,Retinal diseases can lead to severe visual impairment and even blindness, but current treatments are limited. For precise targeted therapy, the pathophysiological mechanisms of the diseases still need to be further explored. Iron serves an essential role in many biological activities and helps maintain the function and morphology of the retina. The vision problems caused by retinal diseases are affecting more and more people, the study of iron metabolism in retinal diseases possesses great potential for clinical application.,Main text,Iron maintains a dynamic balance in the retina but in excess is toxic to the retina. Iron overload can lead to various pathological changes in the retina through oxidative stress, inflammation, cell death, angiogenesis and other pathways. It is therefore involved in the progression of retinal diseases such as age-related macular degeneration, glaucoma, diabetic retinopathy, retinitis pigmentosa, and hereditary iron overload. In recent years, iron chelators have been shown to be effective in the treatment of retinal diseases, but the exact mechanism is not yet fully understood. This question prompted further investigation into the specific mechanisms by which iron metabolism is involved in retinal disease.,Conclusions,This review summarizes iron metabolism processes in the retina and mechanistic studies of iron metabolism in the progression of retinal disease. It also highlights the therapeutic potential of iron chelators in retinal diseases.

Abstract

关键词

Keywords

Iron metabolismRetinaAge-related macular degenerationGlaucomaDiabetic retinopathyRetinitis pigmentosaHereditary iron overload

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