Ophthalmic manifestations in seropositive dengue fever patients during epidemics caused by predominantly different dengue serotypes
- AOPR Vol. 2, Issue 2, Pages: 100049(2022)
- 作者机构：
1. ,Singapore
2. ,Singapore
3. ,Singapore
4. ,Singapore
5. ,India
6. ,Bangalore,India
7. ,Singapore
- 作者简介：
- 基金信息：
DOI：10.1016/j.aopr.2022.100049
CLC：
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Ajeet M. Wagle, Smita R. Hegde, Srinivasan Sanjay, et al. Ophthalmic manifestations in seropositive dengue fever patients during epidemics caused by predominantly different dengue serotypes. [J]. AOPR 2(2):100049(2022)
Ajeet M. Wagle, Smita R. Hegde, Srinivasan Sanjay, et al. Ophthalmic manifestations in seropositive dengue fever patients during epidemics caused by predominantly different dengue serotypes. [J]. AOPR 2(2):100049(2022) DOI： 10.1016/j.aopr.2022.100049.
摘要
Purpose,Dengue fever (DF) epidemics in Singapore in 2005–2006 and 2007 were caused predominantly by dengue virus serotypes 1 (DENV-1) and 2 (DENV-2) respectively. We investigated the prevalence of ophthalmic manifestations during these consecutive epidemics.,Methods,Seropositive DF patients admitted to the hospital during two separate dengue epidemics were enrolled from June 2005 to December 2007. Demographic, ophthalmic, and laboratory data were collected. The primary outcome measures were differences in ophthalmic and laboratory features across the two epidemics. Factors associated with increased risk of developing various DF-related ophthalmic manifestations were the secondary outcome measures.,Results,Of the 115 patients enrolled, 109 (94.7%; 33 in 2005–2006 and 76 in 2007) completed the eye screening protocol. Majority of patients were Chinese (65, 59.6%) and males (81, 74.3%). The mean age was 40.8 years (range, 18–87). Colour vision impairment (12 vs 14 [36.4% vs 18.7%]; ,P, = 0.04), cotton wool spots (10 vs 3 [30.3% vs 3.9%]; ,P, ,<, 0.001), bleeding diathesis (7 vs 3 [21.2% vs 3.9%]; ,P, = 0.004) and abnormal liver function (mean alanine amino-transferase [150.2 U/L vs 68.28 U/L; ,P, = 0.001], mean aspartate amino-transferase [196.86 U/L vs 99.53 U/L; ,P, = 0.002], total protein [68.43 g/L vs 72.27 g/L; ,P, = 0.016], serum albumin [36.86 g/L vs 40.5 g/L; ,P, = 0.001]) were noted more often in DF epidemics predominantly caused by DENV-1 compared to DENV-2.,Conclusions,A higher prevalence of colour vision impairment, cotton wool spots, bleeding diathesis, and abnormal liver function was found in DF epidemics predominantly caused by DENV-1 compared to DENV-2.
Abstract
Purpose,Dengue fever (DF) epidemics in Singapore in 2005–2006 and 2007 were caused predominantly by dengue virus serotypes 1 (DENV-1) and 2 (DENV-2) respectively. We investigated the prevalence of ophthalmic manifestations during these consecutive epidemics.,Methods,Seropositive DF patients admitted to the hospital during two separate dengue epidemics were enrolled from June 2005 to December 2007. Demographic, ophthalmic, and laboratory data were collected. The primary outcome measures were differences in ophthalmic and laboratory features across the two epidemics. Factors associated with increased risk of developing various DF-related ophthalmic manifestations were the secondary outcome measures.,Results,Of the 115 patients enrolled, 109 (94.7%; 33 in 2005–2006 and 76 in 2007) completed the eye screening protocol. Majority of patients were Chinese (65, 59.6%) and males (81, 74.3%). The mean age was 40.8 years (range, 18–87). Colour vision impairment (12 vs 14 [36.4% vs 18.7%]; ,P, = 0.04), cotton wool spots (10 vs 3 [30.3% vs 3.9%]; ,P, ,<, 0.001), bleeding diathesis (7 vs 3 [21.2% vs 3.9%]; ,P, = 0.004) and abnormal liver function (mean alanine amino-transferase [150.2 U/L vs 68.28 U/L; ,P, = 0.001], mean aspartate amino-transferase [196.86 U/L vs 99.53 U/L; ,P, = 0.002], total protein [68.43 g/L vs 72.27 g/L; ,P, = 0.016], serum albumin [36.86 g/L vs 40.5 g/L; ,P, = 0.001]) were noted more often in DF epidemics predominantly caused by DENV-1 compared to DENV-2.,Conclusions,A higher prevalence of colour vision impairment, cotton wool spots, bleeding diathesis, and abnormal liver function was found in DF epidemics predominantly caused by DENV-1 compared to DENV-2.
关键词
Keywords
Dengue feverOphthalmic manifestationsSerotypeEpidemicSingapore
references
1 World Health OrganisationDengue and severe dengue: fact sheet https://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue/, Accessed 14th Oct 2021
2 C. Guo, Z. Zhou, Z. Wen, Y. Liu, et al.Global epidemiology of dengue outbreaks in 1990-2015: a systematic review and meta-analysis Front Cell Infect Microbiol, 317 (2017) 10.3389/fcimb.2017.00317
3 S. Bhatt, P.W. Gething, O.J. Brady, et al.The global distribution and burden of dengue Nature, 496 (2013), pp. 504-507 https://doi:10.1038/nature12060
4 H.M. Srivastava, R. Jan, A. Jan, et al.Fractional-calculus analysis of the transmission dynamics of the dengue infection Chaos, 31 (2021), Article 053130 https://doi:10.1063/5.0050452
5 R. Jan Fatmawati, M.A. Khan, et al.A new model of dengue fever in terms of fractional derivative Math Biosci Eng, 17 (2020), pp. 5267-5288 https://doi:10.3934/mbe.2020285
6 J.K.K. Asamoah, E. Yankson, E. Okyere, et al.Optimal control and cost-effectiveness analysis for dengue fever model with asymptomatic and partial immune individuals Results Phys, 31 (2021), Article 104919 https://doi:10.1016/j.rinp.2021.104919
7 S. Boulaaras, R. Jan, A. Khan, et al.Dynamical analysis of the transmission of dengue fever via Caputo-Fabrizio fractional derivative Chaos, Solit. Fractals, 8 (2022), Article 100072 https://doi:10.1016/j.csfx.2022.100072
8 K.S. Lee, Y.L. Lai, S. Lo, et al.Dengue virus surveillance for early warning, Singapore Emerg Infect Dis, 16 (2010), pp. 847-849 https://doi:10.3201/eid1605.091006
9 D.H. Su, K. Bacsal, S.P. Chee, et al.Prevalence of dengue maculopathy in patients hospitalized for dengue fever Ophthalmology, 114 (2007), pp. 1743-1747 https://doi:10.1016/j.ophtha.2007.03.054
10 H.K. Kapoor, S. Bhai, M. John, et al.Ocular manifestations of dengue fever in an East Indian epidemic Can J Ophthalmol, 41 (2006), pp. 741-746 https://doi:10.3129/i06-069
11 J. Rajarethinam, L.W. Ang, J. Ong, et al.Dengue in Singapore from 2004 to 2016: cyclical epidemic patterns dominated by Serotypes 1 and 2 Am J Trop Med Hyg, 99 (2018), pp. 204-210 https://doi:10.4269/ajtmh.17-0819
12 Ministry of HealthSingapore, Communicable diseases surveillance in Singapore (2005), pp. 3-15 Available from: https://www.moh.gov.sg/resources-statistics/reports/communicable-diseases-surveillance-in-singapore-2005, Accessed 14th Oct 2021
13 Ministry of HealthSingapore, Communicable diseases surveillance in Singapore (2006), pp. 1-13 https://www.moh.gov.sg/resources-statistics/reports/communicable-diseases-surveillance-in-singapore-2006, Accessed 14th Oct 2021
14 Ministry of HealthSingapore, Communicable diseases surveillance in Singapore (2007), pp. 4-15 https://www.moh.gov.sg/resources-statistics/reports/communicable-diseases-surveillance-in-singapore-2007, Accessed 14th Oct 2021
15 C. Cobra, J.G. Rigau-Perez, G. Kuno, et al.Symptoms of dengue fever in relation to host immunologic response and virus serotype, Puerto Rico, 1990-1991 Am J Epidemiol, 142 (1995), pp. 1204-1211 https://doi.org/10.1093/oxfordjournals.aje.a117579
16 A. Balmaseda, S.N. Hammond, L. Perez, et al.Serotype specific differences in clinical manifestations of dengue Am J Trop Med Hyg, 74 (2006), pp. 449-456 PMID: 16525106
17 C.F. Yung, K.S. Lee, T.L. Thein, et al.Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore Am J Trop Med Hyg, 92 (2015), pp. 999-1005 https://doi:10.4269/ajtmh.14-0628
18 D.P. Chan, S.C. Teoh, C.S. Tan, et al.Ophthalmic complications of dengue Emerg Infect Dis, 12 (2006), pp. 285-289 https://doi:10.3201/eid1202.050274
19 E. Chee, J.L. Sims, A. Jap, et al.Comparison of prevalence of dengue maculopathy during two epidemics with differing predominant serotypes Am J Ophthalmol, 148 (2009), pp. 910-913 https://doi:10.1016/j.ajo.2009.06.030
20 J.R. Fried, R.V. Gibbons, S. Kalayanarooj, et al.Serotype-specific differences in the risk of dengue haemorrhagic fever: an analysis of data collected in Bangkok, Thailand from 1994 to 2006 PLoS Neglected Trop Dis, 4 (2010), p. e617 https://doi: 10.1371/journal.pntd.0000617
21 H. Clapham, D.A. Cummings, A. Nisalak, et al.Epidemiology of infant dengue cases illuminates serotype-specificity in the interaction between immunity and disease, and changes in transmission dynamics PLoS Neglected Trop Dis, 9 (2015), Article e0004262 https://doi: 10.1371/journal.pntd.0004262
22 M.G. Guzzman, A. Alvarez, S. Vazquez, et al.Epidemiological studies on dengue virus type 3 in Playa municipality, Havana, Cuba, 2001-2002 Int J Infect Dis, 16 (2012), pp. e198-203 https://doi: 10.1016/j.ijid.2011.09.026
23 T. Kuberski, L. Rosen, D. Reed, et al.Clinical and laboratory observations on patients with primary and secondary dengue type 1 infections with haemorrhagic manifestations in Fiji Am J Trop Med Hyg, 26 (1977), pp. 775-783 https://doi: 10.4269/ajtmh.1977.26.775
24 Y.T. Koh, S. SanjayCharacteristics and ophthalmic manifestations of the classic dengue fever epidemic in Singapore (2005-2006), Asia Pac. J. Ophthalmol. (Phila)., 2 (2013), pp. 99-103 https://doi: 10.1097/APO.0b013e31828a1917
25 T. Somkijrungroj, W. KongwattananonOcular manifestations of dengue Curr Opin Ophthalmol, 30 (2019), pp. 500-505 https://doi: 10.1097/ICU.0000000000000613
26 V.C. Yip, S. Sanjay, Y.T. KohOphthalmic complications of dengue fever: a systematic review Ophthalmol. Ther., 1 (2012), p. 2 https://doi: 10.1007/s40123-012-0002-z
27 B.K. Loh, K. Bacsal, S.P. Chee, et al.Foveolitis associated with dengue fever: a case series Ophthalmologica, 222 (2008), pp. 317-320 https://doi:10.1159/000144074
28 A. Agarwal, K. Aggarwal, M. Dogra, et al.Dengue-induced inflammatory, ischemic foveolitis and outer maculopathy: a swept-source imaging evaluation Ophthalmol. Retina, 3 (2019), pp. 170-177 https://doi: 10.1016/j.oret.2018.09.008
29 M. Li, X. Zhang, Y. Ji, et al.Acute macular neuroretinopathy in dengue fever: short-term prospectively followed up case series JAMA. Ophthalmol., 133 (2015), pp. 1329-1333 https://doi: 10.1001/jamaophthalmol.2015.2687
30 H.M. Yadav, P.D. Majumder, J. BiswasDengue associated choroiditis: a rare entity J. Ophthalmic. Inflamm. Infect., 7 (2017), p. 14, 10.1186/s12348-017-0132-5
31 S. Kanungo, D. Shukla, R. KimBranch retinal artery occlusion secondary to dengue fever Indian J Ophthalmol, 56 (2008), pp. 73-74 https://doi:10.4103/0301-4738.37606
32 K.E. Bacsal, S.P. Chee, C.L. Cheng, et al.Dengue-associated maculopathy Arch Ophthalmol, 125 (2007), pp. 501-510 https://doi:10.1001/archopht.125.4.501
33 J. Venkatramani, W.K. LimBilateral vitreous haemorrhage associated with dengue fever Eye, 20 (2006), pp. 1405-1406 https://doi:10.1038/sj.eye.6702259
34 S. Sanjay, A.M. Wagle, K.G. Au EongOptic neuropathy associated with dengue fever Eye, 22 (2009), pp. 722-724 https://doi:10.1016/j.ophtha.2008.08.015
35 R.C. Seet, A.M. Quek, E.C. LimSymptoms and risk factors of ocular complications following dengue infection J Clin Virol, 38 (2007), pp. 101-105 https://doi:10.1016/j.jcv.2006.11.002
36 W.K. Lim, R. Mathur, A. Koh, et al.Ocular manifestations of dengue fever Ophthalmology, 111 (2004), pp. 2057-2064 https://doi:10.1016/j.ophtha.2004.03.038
37 V. Cruz-Villegas, A.M. Berrocal, J.L. DavisBilateral choroidal effusions associated with dengue fever Retina, 23 (2003), pp. 576-578 https://doi:10.1097/00006982-200308000-00031
38 T. Somkijrungroj, W. KongwattananonOcular manifestations of dengue Curr Opin Ophthalmol, 30 (2019), pp. 500-505 https://doi:10/1097/ICU.0000000000000613
39 S. Sanjay, S. Agrawal, P. Jain, et al.Permanent visual impairment in dengue fever following platelet transfusion: a series of 5 cases Ann Acad Med Singapore, 50 (2021), pp. 588-592 https://doi:10.47102/annals-acadmedsg.202154
40 S. Sanjay, A. Anilkumar, P. Mahendradas, et al.Inflammatory branch retinal artery and vein occlusion with panuveitis secondary to dengue fever Indian J Ophthalmol, 68 (2020), pp. 1958-1960 https://doi:10.4103/ijo.IJO_1368_20
41 P. Mahendradas, S. Sanjay, A. Kawali, et al.Commentary: evidence of dengue virus in eviscerated specimens of panophthalmitis secondary to dengue fever: a possible cause-effect phenomenon Indian J Ophthalmol, 70 (2022), p. 970 https://doi:10.4103/ijo.IJO_2604_21
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